the pparαp16ink4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase acti

the pparαp16ink4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase acti Here,we show that PPARαcontrols SMC cell-cycleprogression at the G 1 /S transition by targeting the cyclin-dependent kinase inhibitorand tumor suppressor p16 INK4a(p16),resulting in an inhibi...